Brendan Fraser plays John Crowley, a biotechnology executive whose two youngest children were afflicted with Pompe disease or acid maltase deficiency. Along with his wife Aileen (Keri Russell), he raises money for research scientist Robert Stonehill (Harrison Ford), forming a company to develop a drug to save his children’s lives. Dr. Stonehill is a composite of the many great scientists and researchers that researched for a cure over the years, among them Drs Arnold Reuser, Ans van der Ploeg, William Canfield and Dr. Yuan-Tsong Chen.[3]
The film centers on the Crowleys’ two dying children, aged 9 and 7. In real life, most children with Pompe disease would die before age 2. There is also a juvenile and adult form which can present at almost any age. Those in the real story were 15 months and 7 days old when they got sick. They were 5 and 4 years old when treatment began.
Adapted by Robert Nelson Jacobs from a nonfiction book by the journalist Geeta Anand, the film is also an examination of how medical research is conducted and financed.
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| Directed by | Tom Vaughan |
|---|---|
| Produced by | Michael Shamberg Stacey Sher Carla Santos Shamberg Harrison Ford (executive producer |
| Written by | Robert Nelson Jacobs (screenplay) Geeta Anand (book) |
| Starring | Brendan Fraser Harrison Ford Keri Russell |
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